An Overview of Sustiva (Efavirenz, Stocrin)
September 13, 2012
Brand Name: Sustiva
Efavirenz can cause serious, life-threatening side effects. These include serious psychiatric problems and liver problems.
Contact your health care provider right away if you have any of the following symptoms that may signal psychiatric problems:
Some people taking efavirenz have experienced serious liver problems. This usually occurred in people with a chronic liver disease (such as hepatitis infection), but there have also been a few reports in people without any existing liver disease. Tell your health care provider if you notice any side effects while taking efavirenz.
Women should not become pregnant while taking efavirenz and for 12 weeks after stopping the drug. Serious birth defects have been seen in the babies of animals and women treated with efavirenz during pregnancy. Whether efavirenz caused the birth defects is unknown.
While taking efavirenz, it is important to keep all of your appointments with your health care provider.
What is efavirenz?
Efavirenz is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Efavirenz is also approved for use in children 3 years of age and older who weigh at least 10 kilograms. Efavirenz is always used in combination with other anti-HIV medicines.
Efavirenz is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
Efavirenz does not cure HIV/AIDS. It is not known if efavirenz reduces the risk of passing HIV to other people.
What should I tell my health care provider before taking efavirenz?
Before taking efavirenz, tell your health care provider:
How should I take efavirenz?
Efavirenz comes in two forms:
Take efavirenz according to your health care provider's instructions.
Take efavirenz on an empty stomach and without food, preferably at bedtime. Swallow efavirenz with water.
Always take efavirenz in combination with other anti-HIV medicines.
If you take too much efavirenz, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.
For more information on how to take efavirenz, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What side effects can efavirenz cause?
Efavirenz can cause serious, life-threatening side effects. These include serious psychiatric problems and liver problems.(See the WARNING above.)
Other possible side effects of efavirenz include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of efavirenz. Ask your health care provider or pharmacist for more information on possible side effects of efavirenz.
How should efavirenz be stored?
Where can I find more information about efavirenz?
More information about efavirenz is available:
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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