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An Overview of Combivir (AZT/3TC)

August 23, 2013

la-MI-vyoo-deen, zye-DOE-vyoo-deen

Combivir

Brand Name: Combivir
Other Name(s): 3TC/ZDV
Drug Class: Nucleoside Reverse Transcriptase Inhibitors
Approved Use: Treatment of HIV Infection

WARNING:

Combivir can cause serious, life-threatening side effects. These include blood disorders (including severe anemia), lactic acidosis (a buildup of acid in the blood), liver problems, and muscle disorders.

Contact your health care provider right away if you have any of the following symptoms that may signal a blood disorder:

Contact your health care provider right away if you have any of the following symptoms that may signal lactic acidosis:

Contact your health care provider if you have any of the following symptoms that may signal liver problems:

Tell your health care provider if you have or have ever had any disease or swelling of the muscles. Contact your health care provider right away if have muscle pain or weakness.

Severe worsening of liver disease has occurred in some people co-infected with hepatitis B virus (HBV) and HIV when they stopped treatment with lamivudine, an anti-HIV medicine included in Combivir. Worsening of liver disease, sometimes causing death, has also occurred in people co-infected with hepatitis C virus (HCV) and HIV who were taking anti-HIV medicines and also being treated for HCV with interferon with or without ribavirin. Tell your health care provider about any side effects you have.

While taking Combivir, it is important to keep all of your appointments with your health care provider.


What is Combivir?

Combivir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children. Combivir is always used in combination with other anti-HIV medicines.

Combivir contains the following two anti-HIV medicines combined in one pill: lamivudine and zidovudine. Lamivudine and zidovudine are types of anti-HIV medicines called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.

Combivir does not cure HIV/AIDS. It is not known if Combivir reduces the risk of passing HIV to other people.


What should I tell my health care provider before taking Combivir?

Before taking Combivir, tell your health care provider:


How should I take Combivir?

Combivir comes in tablet form. Each tablet contains:

Take Combivir according to your health care provider's instructions.

Always take Combivir in combination with other anti-HIV medicines. Take Combivir with or without food.

If you take too much Combivir, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.

For more information on how to take Combivir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What should I do if I forget a dose?

Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.


What side effects can Combivir cause?

Combivir can cause serious, life-threatening side effects. These include blood disorders, lactic acidosis (a buildup of acid in the blood), liver problems, and muscle disorders. (See the WARNING above.)

Other possible side effects of Combivir include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Combivir. Ask your health care provider or pharmacist for more information on side effects of Combivir.


How should Combivir be stored?


Where can I find more information about Combivir?

More information about Combivir is available:


Manufacturer Information

GlaxoSmithKline
888-825-5249




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