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An Overview of Atripla (Efavirenz/Tenofovir/FTC)

December 31, 2014

Atripla

Brand Name: Atripla
Other Name(s): efavirenz/emtricitabine/tenofovir, efavirenz/emtricitabine/tenofovir DF, EFV/FTC/TDF
Drug Class: Combination Drugs
Approved Use: Treatment of HIV Infection

Chemical Images:

efavirenz

efavirenz
Molecular Weight: 315.677

emtricitabine

emtricitabine
Molecular Weight: 247.249

tenofovir disoproxil fumarate

tenofovir disoproxil fumarate
Molecular Weight: 635.5166


WARNING:

Atripla can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems.

Contact your health care provider right away if you have any of the following symptoms that may be signs of lactic acidosis:

Contact your health care provider right away if you have any of the following symptoms that may be signs of liver problems:

Atripla is not approved for the treatment of hepatitis B virus (HBV) infection. If you have both HIV and HBV infection and take Atripla, your HBV infection may get worse (flare up) if you stop taking Atripla. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Atripla.

If you take Atripla, you should not take certain other HIV medicines.

While taking Atripla, it is important to keep all of your appointments with your health care provider.


What Is Atripla?

Atripla is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 12 years of age and older. Atripla can be used alone as a complete treatment regimen or with other HIV medicines.

Atripla contains the following three different HIV medicines combined in one pill:

Both NNRTIs and NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, the three drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.


What Should I Tell My Health Care Provider Before Taking Atripla?

Before taking Atripla, tell your health care provider:


How Should I Take Atripla?

Atripla comes in tablet form. Each tablet contains:

Take Atripla according to your health care provider's instructions.

Take Atripla on an empty stomach and without food, preferably at bedtime. Swallow the pill with water.

If you take too much Atripla, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take Atripla, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What Should I Do if I Forget a Dose?

If you miss a dose of Atripla, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.


What Side Effects Can Atripla Cause?

Atripla can cause serious, life-threatening side effects. These include lactic acidosis (buildup of lactic acid in the blood) and liver problems. (See the WARNING above).

Other possible side effects of Atripla include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Atripla. To learn more about possible side effects of Atripla, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to Atripla.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.


How Should Atripla Be Stored?


Where Can I Find More Information About Atripla?

More information about Atripla is available:


Manufacturer Information

Bristol-Myers Squibb
800-332-2056

Gilead Sciences, Inc.
800-445-3235

The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).




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