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An Overview of Atripla (Efavirenz/Tenofovir/FTC)

August 23, 2013

ef-FAH-ver-enz / em-tri-SIT-uh-bean / te-NOE-fo-veer

Atripla

Brand Name: Atripla
Other Name(s): EFV/FTC/TDF
Drug Class: Combination Drugs
Approved Use: Treatment of HIV Infection

WARNING:

Atripla can cause serious, life-threatening side effects. These include lactic acidosis (buildup of acid in the blood) and liver problems.

Contact your health care provider right away if you have any of the following symptoms that may signal lactic acidosis:

Contact your health care provider right away if you have any of the following symptoms that may signal liver problems:

Atripla is not approved for the treatment of hepatitis B virus (HBV) infection. People coinfected with HIV and HBV who stopped taking emtricitabine or tenofovir disoproxil fumarate, which are two anti-HIV medicines included in Atripla, had severe worsening of their HBV infections.

While taking Atripla, it is important to keep all of your appointments with your health care provider.


What is Atripla?

Atripla is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Atripla can be used alone as a complete treatment regimen or in combination with other anti-HIV medicines.

Atripla contains the following three anti-HIV medicines combined in one pill: efavirenz, emtricitabine, and tenofovir disoproxil fumarate. Emtricitabine and tenofovir disoproxil fumarate are types of anti-HIV medicines called nucleoside reverse transcriptase inhibitors (NRTIs). Efavirenz is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). The three drugs in combination help block HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.

Atripla does not cure HIV/AIDS. It is not known if Atripla reduces the risk of passing HIV to other people.


What should I tell my health care provider before taking Atripla?

Before taking Atripla, tell your health care provider:


How should I take Atripla?

Atripla comes in tablet form. Each tablet contains:

Take Atripla according to your health care provider's instructions.

Take Atripla on an empty stomach and without food, preferably at bedtime. Swallow the pill with water.

If you take too much Atripla, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.

For more information on how to take Atripla, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What should I do if I forget a dose?

Take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.


What side effects can Atripla cause?

Atripla can cause serious, life-threatening side effects. These include lactic acidosis (buildup of acid in the blood) and liver problems. (See the WARNING above).

Other possible side effects of Atripla include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Atripla. Ask your health care provider or pharmacist for more information on side effects of Atripla.


How should Atripla be stored?


Where can I find more information about Atripla?

More information about Atripla is available:


Manufacturer Information

Bristol-Myers Squibb
800-332-2056

Gilead Sciences
800-445-3235




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