Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

Medical News

Extensively Drug-Resistant Tuberculosis as a Cause of Death in Patients Co-Infected With Tuberculosis and HIV in a Rural Area of South Africa

November 21, 2006

The authors of the current study noted the close association between HIV-1 and TB in South Africa. In the sub-Saharan Africa, TB is the most common cause of morbidity and mortality for people infected with HIV-1. In South Africa, while antiretroviral therapy has helped to decrease AIDS mortality among patients who are TB-co-infected, drug-resistant TB has surfaced as a major cause of death. In this context, researchers assessed the prevalence and consequences of multidrug-resistant (MDR) and extensively drug-resistant TB (XDR-TB)in the Msinga sub-district of KwaZulu Natal, South Africa.

The investigators conducted enhanced surveillance for drug-resistant TB with sputum culture and drug susceptibility testing in patients with known or suspected TB. Isolates resistant to first- and second-line drugs were genotyped.

Sputum was obtained from 1,539 patients between January 2005 and March 2006. MDR-TB was detected in 221 patients, among whom 53 had XDR-TB. Among 475 culture-confirmed TB patients, MDR-TB prevalence was 39 percent (185 patients) and 6 percent (30) for XDR-TB. Fifty-five percent of XDR-TB patients had not been previously treated for TB (26 of 47 patients); but 67 percent had a recent hospital admission (28 of 42 patients). All 44 patients with XDR-TB who were tested for HIV were co-infected. Fifty-two of 53 XDR-TB patients died, with an average survival of 16 days after diagnosis among the 42 patients with confirmed dates of death. Genotyping of isolates showed 39 of 46 XDR-TB patients had similar strains (85 percent; 95 percent confidence interval, 74-95).

Advertisement
"MDR tuberculosis is more prevalent than previously realised in this setting," researchers concluded. "XDR tuberculosis has been transmitted to HIV co-infected patients and is associated with high mortality. These observations warrant urgent intervention and threaten the success of treatment programmes for tuberculosis and HIV."

Back to other news for November 21, 2006

Adapted from:
The Lancet
11.04.2006; Vol. 368; No. 9547: P. 1575-1580; Neel R. Gandhi; Anthony Moll; A. Willem Sturm; Robert Pawinski; Thiloshini Govender; Umesh Lalloo; Kimberly Zeller; Jason Andrews; Gerald Friedland


  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
 
See Also
More HIV News

Tools
 

Advertisement