An Overview of Intelence (TMC125, Etravirine)
November 23, 2016
Brand Name: Intelence
Etravirine can cause serious, life-threatening side effects. These include severe rash and allergic reactions.
Contact your health care provider right away if you have a rash. Stop taking etravirine and contact your health care provider right away if you have a rash along with any of the following symptoms:
While taking etravirine, it is important to keep all of your appointments with your health care provider.
What Is Etravirine?
Etravirine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 6 years of age and older.
Etravirine belongs to a class (group) of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs attach to and block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
Etravirine is always used in combination with other HIV medicines. Etravirine is used in people who are already taking or have taken an NNRTI plus other HIV medicines and in whom these medicines are not controlling their HIV infection.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
What Should I Tell My Health Care Provider Before Taking Etravirine?
Before taking etravirine, tell your health care provider:
How Should I Take Etravirine?
Etravirine (brand name: Intelence) comes in tablet form in three different strengths:
Take etravirine according to your health care provider's instructions.
Always take etravirine after a meal. Do not take etravirine on an empty stomach. Swallow the tablets whole with a glass of water. Do not chew the tablets.
If you are unable to swallow the etravirine tablets whole, place the tablets in a glass containing a teaspoon of water. (If needed, add more water to cover the tablets.) Do not put the tablets in other liquids. Stir well until the water looks milky. At this step, you may add a small amount of water, orange juice, or milk to make the mixture easier to drink. Then drink the mixture right away. Rinse the glass with water, orange juice, or milk several times, and completely swallow the rinse each time to make sure you take the entire dose of etravirine. Avoid using grapefruit juice or warm (more than 104°F/40°C) or carbonated beverages when taking etravirine tablets.
Always take etravirine in combination with other HIV medicines.
If you take too much etravirine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take etravirine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.