An Overview of Prezista (Darunavir, TMC114)
March 5, 2013
Brand Name: Prezista
Darunavir can cause serious, life-threatening side effects. These include liver problems and severe skin reactions or rash.
Contact your health care provider right away if you have any of the following symptoms that may signal liver problems:
Contact your health care provider right away if you develop a rash. Stop taking darunavir (and ritonavir, the anti-HIV medicine always used with darunavir) and contact your health care provider immediately if you develop any skin changes along with the following symptoms:
Taking darunavir with certain other medicines may cause serious side effects.
While taking darunavir, it is important to keep all of your appointments with your health care provider.
What is darunavir?
Darunavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 years of age and older. Darunavir is always used in combination with the anti-HIV medicine ritonavir (brand name: Norvir) and other anti-HIV medicines.
Darunavir is a type of anti-HIV medicine called a protease inhibitor (PI). Darunavir works by blocking protease, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
Darunavir does not cure HIV/AIDS. It is not known if darunavir reduces the risk of passing HIV to other people.
What should I tell my health care provider before taking darunavir?
Before taking darunavir, tell your health care provider:
How should I take darunavir?
Darunavir comes in the following forms and strengths:
Take darunavir according to your health care provider's instructions.
Always take darunavir in combination with the anti-HIV medicine ritonavir (brand name: Norvir) and other anti-HIV medicines.
Take darunavir and ritonavir at the same time with food. Swallow darunavir tablets whole with a drink. Take (or give) darunavir oral suspension with the oral dosing syringe that comes with the medicine. Shake the oral suspension well before each use.
If you take too much darunavir, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.
For more information on how to take darunavir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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