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An Overview of Aldesleukin (IL-2, Proleukin)

October 30, 2016

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References

  1. United States National Library of Medicine. ChemIDplus Advanced. Available at: https://chem.sis.nlm.nih.gov/chemidplus/rn/110942-02-4. Last accessed on October 30, 2016.
  2. Gougeon ML, Chiodi F. Impact of γ-chain cytokines on T cell homeostasis in HIV-1 infection: therapeutic implications. J Intern Med. 2010 May; 267(5): 502-14. Available at: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2010.02221.x/full. Last accessed on October 30, 2016.
  3. Novartis Pharmaceuticals Corporation. PROLEUKIN- aldesleukin injection: Full Prescribing Information, December 26, 2009. DailyMed. Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a588140c-f9ed-4a9b-a9a6-bf3daafd8a5a. Last accessed on October 30, 2016.
  4. National Institute of Allergy and Infectious Diseases (NIAID). A Randomized, Open-Label, Phase III, International Study of Subcutaneous Recombinant IL-2 in Patients With HIV-1 Infection and CD4+ Cell Counts 300/mm^3 or Greater: Evaluation of Subcutaneous Proleukin in a Randomized International Trial. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on March 10, 2000. NLM Identifier: NCT00004978. Available at: https://clinicaltrials.gov/ct2/show/NCT00004978. Last accessed on October 30, 2016.
  5. University of Minnesota - Clinical and Translational Science Institute. A Phase III Multicenter Randomized Study of the Biological and Clinical Efficacy of Subcutaneous Recombinant, Human Interleukin-2 in HIV-Infected Patients With Low CD4+ Counts Under Active Antiretroviral Therapy (SILCAAT Amendment 4). In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on March 24, 2001. NLM Identifier: NCT00013611. Available at: https://clinicaltrials.gov/ct2/show/NCT00013611. Last accessed on October 30, 2016.
  6. Barouch DH, Deeks SG. Immunologic Strategies for HIV-1 Remission and Eradication. Science. 2014 Jul 11; 345(6193): 169-174. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4096716/. Last accessed on October 30, 2016.
  7. Lederman MM, Rodriguez B, Sieg S. Immunopathogenesis of HIV Infection. In: Coffey S and Volberding P, eds. HIV InSite Knowledge Base. University of California San Francisco; 2004. Available at: http://hivinsite.ucsf.edu/InSite?page=kb-00&doc=kb-02-01-04. Last accessed on October 30, 2016.
  8. Kedzierska K, Crowe SM. Cytokines and HIV-1: interactions and clinical implications. Antivir Chem Chemother. 2001 May; 12(3): 133-50. Available at: www.ncbi.nlm.nih.gov/pubmed/12959322. Last accessed on October 30, 2016.
  9. Siliciano RF, Greene WC. HIV Latency. Cold Spring Harb Perspect Med. 2011 Sep; 1(1): a007096. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC3234450/. Last accessed on October 30, 2016.
  10. Savarino A, Shytaj IL. Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS. Retrovirology. 2015; 12: 51. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4472405/. Last accessed on October 30, 2016.
  11. Paredes R, López Benaldo de Quirós JC, Fernández-Cruz E, Clotet B, Lane HC. The Potential Role of Interleukin-2 in Patients with HIV Infection. AIDS Rev. 2002 Jan-Mar; 4(1): 36-40. Available at: www.aidsreviews.com/files/2002_04_1_036-040.pdf. Last accessed on October 30, 2016.
  12. Abrams D, Lévy Y, Losso MH, et al. Interleukin-2 Therapy in Patients with HIV Infection. N Engl J Med. 2009 Oct 15; 361(16): 1548-1559. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC2869083/. Last accessed on October 30, 2016.
  13. Sued O, Ambrosioni J, Nicolás D, et al. Structured Treatment Interruptions and Low Doses of IL-2 in Patients with Primary HIV Infection. Inflammatory, Virological and Immunological Outcomes. PLoS One. 2015 Jul 17; 10(7): e0131651. Available at: http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0131651.PDF. Last accessed on October 30, 2016.
  14. Stellbrink HJ, van Lunzen J, Westby M, et al. Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial). AIDS. 2002 Jul 26; 16(11): 1479-87. Available at: www.ncbi.nlm.nih.gov/pubmed/12131185. Last accessed on October 30, 2016.
  15. University of Pennsylvania. A Phase I/II Study Of the Safety, Survival, and Trafficking of Autologous CD4-ZETA Gene-Modified T Cells With and Without Extension Interleukin-2 in HIV Infected Patients. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on November 5, 2009. NLM Identifier: NCT01013415. Available at: https://clinicaltrials.gov/ct2/show/NCT01013415. Last accessed on October 30, 2016.
  16. National Institutes of Health (NIH). NIH Clinical Research Trials and You. Available at: www.nih.gov/health-information/nih-clinical-research-trials-you. Last accessed on October 30, 2016.
  17. National Institute of Allergy and Infectious Diseases (NIAID). Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Anti-Retroviral TX in HIV Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm(3) Who Have Received Anti-Retroviral TX. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on November 3, 2003. NLM Identifier: NCT00071890. Available at: https://clinicaltrials.gov/ct2/show/NCT00071890. Last accessed on October 30, 2016.
  18. Tavel JA. Effects of Intermittent IL-2 Alone or with Peri-Cycle Antiretroviral Therapy in Early HIV Infection: The STALWART Study. PLoS One. 2010; 5(2): e9334. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC2826395/. Last accessed on October 30, 2016.
  19. National Institute of Allergy and Infectious Diseases (NIAID). STALWART: A Randomized, Open-Label, International Study of Subcutaneous Recombinant Interleukin-2 With and Without Concomitant Antiretroviral Therapy in Patients With HIV-1 Infection and CD4+ Cell Counts of 300 Cells/mm3 or More. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on May 13, 2005. NLM Identifier: NCT00110812. Available at: https://clinicaltrials.gov/ct2/show/study/NCT00110812. Last accessed on October 30, 2016.
  20. Molina JM, Levy Y, Fournier I, et al. Interleukin-2 before Antiretroviral Therapy in Patients with HIV Infection: A Randomized Trial (ANRS 119). J Infect Dis. 2009 Jul 15; 200(2): 206-15. Available at: http://jid.oxfordjournals.org/content/200/2/206.long. Last accessed on October 30, 2016.
  21. French National Agency for Research on AIDS and Viral Hepatitis. Study of the Immunological Efficacy of Using Subcutaneous Interleukin-2 (IL-2) in Antiretroviral Naïve HIV-1-Infected Subjects With a CD4 Cell Count Above 300/mm3. ANRS 119 Trial INTERSTART. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). Registered on July 8, 2005. NLM Identifier: NCT00120185. Available at: https://clinicaltrials.gov/show/NCT00120185. Last accessed on October 30, 2016.
  22. Treatment Action Group website. Research Toward a Cure Trials. Available at: www.treatmentactiongroup.org/cure/trials. Last accessed on October 30, 2016.
  23. Lévy Y, Thiébaut R, Gougeon ML, et al. Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV. AIDS. 2012 Mar 27; 26(6): 711-20. Available at: http://journals.lww.com/aidsonline/Fulltext/2012/03270/Effect_of_intermittent_interleukin_2_therapy_on.7.aspx. Last accessed on October 30, 2016.
  24. National Institutes of Health (NIH): News Release, dated February 10, 2009. IL-2 Immunotherapy Fails to Benefit HIV-Infected Individuals Already Taking Antiretrovirals. Available at: www.nih.gov/news-events/il-2-immunotherapy-fails-benefit-hiv-infected-individuals-already-taking-antiretrovirals. Last accessed on October 30, 2016.
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