"Trizivir" Approved: Three Existing Drugs in One
November 17, 2000
On November 15 the FDA approved Trizivir®, a product that combines adult doses of three previously approved Glaxo-Wellcome drugs -- AZT, 3TC, and abacavir -- into a single tablet. The rationale is that taking only one tablet twice a day without regard to food may improve adherence in some patients. Some activists are concerned that this treatment might be chosen for institutional convenience (for example when treating prisoners) even when it is not the best medical option for the individual.
The following writeup was released November 15 by the AIDS Treatment Information Service, an agency which provides AIDS treatment information for the U.S. government:
November 15, 2000: The Food and Drug Administration (FDA) today approved Trizivir for the treatment of HIV in adults and adolescents. Each dose of Trizivir is a fixed-dose combination of Ziagen (abacavir/ABC), Retrovir (zidovudine/AZT), and Epivir (lamivudine/3TC), three nucleoside reverse transcriptase inhibitors (NRTIs) already approved by FDA. Trizivir is not recommended for treatment in adults or adolescents who weigh less than 40 kilograms because it is a fixed-dose tablet.
Copyright 2000 by John S. James. Permission granted for noncommercial reproduction, provided that our address and phone number are included if more than short quotations are used.
This article was provided by AIDS Treatment News. It is a part of the publication AIDS Treatment News.