Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary
  • PDF PDF

Tuberculosis: Guidelines Changed for Latent TB Treatment

September 21, 2001

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

The U.S. Centers for Disease Control and the American Thoracic Society have issued new guidelines calling for more caution in using the two-month regimen of rifampin and pyrazinamide. The change resulted from reports of 21 cases of severe liver injury with the two-drug regimen. Five of these patients died, and 16 recovered.

The new guidelines were published in the August 31, 2001 MMWR (Morbidity and Mortality Weekly Report), volume 50, number 34, pages 733-735. We cannot summarize them because there are many special cases. For most patients, especially those who are HIV-negative, the older nine-month regimen of isoniazid (INH) should be used. For persons with HIV, the guidelines include the following:

"Available data do not suggest excessive risk for severe hepatitis associated with RIF-PZA treatment among HIV-infected persons. In a large multinational trial, HIV-infected patients treated with RIF-PZA had lower rates of serum aminotransferarase (AT) elevations than those given INH alone. The RIF-PZA regimen also was well tolerated when given twice weekly to HIV-infected persons in Zambia and Haiti. However, experience from trials may not translate to all clinical practice settings, and it may be prudent to use 9 months of daily INH for treatment of HIV-infected persons with LBTI [latent TB infection] when completion of treatment can be assured."

The August 31 MMWR is available at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5034a1.htm. Click here to download the PDF.

Advertisement

ISSN # 1052-4207

Copyright 2001 by John S. James. Permission granted for noncommercial reproduction, provided that our address and phone number are included if more than short quotations are used.


Back to the AIDS Treatment News September 21, 2001 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary
  • PDF PDF

This article was provided by AIDS Treatment News. It is a part of the publication AIDS Treatment News.
 
See Also
Tuberculosis (TB) Fact Sheet
Questions and Answers About Tuberculosis
More on Treating Tuberculosis and HIV/AIDS

Tools
 

Advertisement