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Warning Against Tenofovir+ddI+3TC, and "Triple Nuke" Combinations

October 31, 2003

On October 14, 2003 Gilead Sciences warned health care professionals against a using ddI plus 3TC plus tenofovir combination, after many patients on that regimen failed to control the virus and developed mutations to the drugs. The "dear doctor" letter, "High Rate of Virologic Failure in Patients with HIV Infection Treated with a Once-Daily Triple NRTI Regimen containing Didanosine, Lamivudine, and Tenofovir" is on the FDA Website, www.fda.gov/medwatch/SAFETY/2003/viread_deardoc.pdf.

The letter also cautioned against all-NRTI regimens in general, as three other such regimens showed disappointing antiviral results in clinical trials.


ISSN # 1052-4207

Copyright 2003 by John S. James. Permission granted for noncommercial reproduction, provided that our address and phone number are included if more than short quotations are used.

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This article was provided by AIDS Treatment News. It is a part of the publication AIDS Treatment News.
 

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