U.S. Centers for Disease Control and Prevention

1997 Revised Guidelines for Performing CD4+ T-Cell Determinations in Persons Infected with Human Immunodeficiency Virus (HIV)

APPENDIX. Effects of medications and other biologic factors on immunophenotyping results

Causative agent	Effect	Result
Zidovudine (AZT)	Increased granuloctye fragility; red blood cells (RBCs) less susceptible to lysing reagents	Poor light-scattering (increased granulocyte and RBC contamination of lymphocyte gates)
Some antibiotics (e.g., cephalosporins)	Increased cellular auto-fluorescence	Increased autofluorescence
Corticosteroids	Decreased CD4+ T-cell levels	Decreased CD4+ T-cell percentage and absolute number
Strenuous exercise	Decreased lymphocyte counts	Lower absolute lymphocyte subset values
Diurnal variation	Changes in absolute lymphocyte counts	Variable absolute lymphocyte subset values (not as prevalent in human immunodeficiency virus infection)

*49 CFR parts 100-171 (56 FR 47158).
**42 CFR part 493 § 493.801-493.865.

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This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication Morbidity and Mortality Weekly Report.

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