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Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease

Terms and Abbreviations

October 16, 1998

Acute hepatitis C Newly acquired symptomatic hepatitis C virus (HCV) infection.
ALT Alanine aminotransferase.
Anti-HCV Antibody to HCV that develops in response to HCV infection; detectable in persons with acute, chronic, and resolved infection.
AST Aspartate aminotransferase.
Chronic (persistent) HCV infection Persistent infection with HCV; characterized by detection of HCV RNA 6 months after newly acquired infection.
Chronic hepatitis C Liver inflammation in patients with chronic HCV infection; characterized by abnormal levels of liver enzymes.
CSTE Council of State and Territorial Epidemiologists.
DNA Deoxyribonucleic acid.
EIA Enzyme immunoassay.
FDA U.S. Food and Drug Administration.
HBV Hepatitis B virus.
HCC Hepatocellular carcinoma.
HCV Hepatitis C virus.
HCV-positive Positive for anti-HCV as verified by supplemental testing or positive for HCV RNA.
HCV RNA Hepatitis C virus ribonucleic acid.
HIV Human immunodeficiency virus.
IG Immune globulin.
IM Intramuscular.
IV Intravenous.
MSM Men who have sex with men.
NHANES III Third National Health and Nutrition Examination Survey.
NIH National Institutes of Health.
Positive predictive value Probability that a positive screening test is truly positive; dependent on prevalence of disease in a population.
Qualitative RT-PCR for HCV RNA Test to detect HCV RNA by amplification of viral genetic sequences.
Quantitative assays for HCV RNA Tests to detect HCV RNA concentration (viral load) by amplification of viral genetic sequences or by signal amplification.
Resolved HCV infection Recovery following hepatitis C virus infection; characterized by sustained disappearance of serum HCV RNA and normalization of liver enzymes.
RIBATM Recombinant immunoblot assay.
RNA Ribonucleic acid.
RT-PCR Reverse transcriptase polymerase chain reaction.
STD Sexually transmitted disease.
Supplemental anti-HCV test Additional test (i.e.,RIBATM) used to verify a positive anti-HCV result obtained by EIA.

  
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This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication Morbidity and Mortality Weekly Report.
 

 

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