Print this page    •   Back to Web version of article

Medical News
Drug-Resistant HIV Passed Through Breast Milk

February 13, 2003

HIV-infected women given a single dose of the AIDS drug nevirapine during labor to prevent them from transmitting the virus to their baby harbor HIV in their breast milk that is resistant to the drug, according the results of a small clinical trial.

The concentration of drug-resistant virus in breast milk was significantly higher than levels detected in the blood, Dr. E. Lee of Stanford University in Palo Alto reported Wednesday at the 10th Conference on Retroviruses and Opportunistic Infections in Boston.

Lee and colleagues at Stanford and at the University of Zimbabwe-Harare followed HIV-infected women in Chitungwiza, Zimbabwe, who participated in a study in which they received a single dose of nevirapine at the onset of labor. The women were subsequently monitored for HIV levels in plasma and breast milk at two, eight, 16 and 20 weeks after delivery. Complete information was available for plasma samples and breast milk samples for 33 and 20 women, respectively.

After eight weeks, mutations in breast milk associated with nevirapine resistance were detected in 13 of the 20 women (65 percent), while such mutations were found in plasma in eight of the 33 women (40 percent). Four infants had confirmed HIV infection. The most common mutation the researchers found is known to confer resistance to other drugs in the same class as nevirapine, non-nucleoside reverse transcriptase inhibitors.

Dr. Constance A. Benson of the University of Colorado Health Science Center in Denver, who did not participate in the study, said the findings do not warrant a change in policy. In settings where health care resources are scarce, she explained, the benefits of giving laboring HIV-positive women nevirapine to prevent their baby from becoming infected probably still outweigh the risks.

Back to other CDC news for February 13, 2003

Previous Updates

Excerpted from:
Reuters Health
02.12.03; Deborah Mitchell




This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. You can find this article online by typing this address into your Web browser:
http://www.thebody.com/content/art29224.html

General Disclaimer: TheBody.com is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through TheBody.com should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.