Antiretroviral Treatment Increases Adult Thymic Volume
January 15, 2003
Researchers in Spain found that HAART increases thymus size in adult HIV patients. "An important thymus role has been suggested in T-cell repopulation after HAART in adult HIV-1 infected patients," according to A. Rubio and colleagues at the University of Seville and Virgen del Rocio University Hospital in Seville.Adapted from:
The researchers evaluated thymic size in 21 adult HIV patients 12 and 24 weeks after HAART was initiated. They found that HAART significantly improved thymic volume in patients after 24 weeks. The report notes that significant elevations in overall CD4 cell counts and increased production of naive T cells accompanied the increased thymus size. Previous studies had associated increased thymus size and HAART in pediatric patients.
"These data show the first evidence of early change in thymic volume of adult HIV-1-infected patients under HAART," Rubio and colleagues concluded. "This increase was related to the rise of both total and naive CD4+ cell counts suggesting a functional role of thymic volume increase." The study, "Changes in Thymus Volume in Adult HIV-Infected Patients under HAART: Correlation with the T-Cell Repopulation," was published in Clinical and Experimental Immunology (2002;130(1):121-126).
12.20.02; Michael Greer
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.