March 12, 2003
Thirty patients -- 15 coinfected with HIV and HCV, and 15 age-matched patients with HCV alone -- took high-dose IFN-alpha-2a therapy for 24 weeks. The report states that HIV viral loads dropped from roughly 7,410 copies/mL to 320 copies/mL after two weeks. Data showed that HCV RNA was undetectable in four of 12 evaluable HIV-positive patients, and in six of 15 HCV-alone patients after 24 weeks. Three HIV-positive patients had to discontinue treatment because of IFN-related toxicity.
"Induction therapy and the dose of IFN should be evaluated in combination therapy with IFN and ribavirin," Hanabusa concluded. The full report, "Efficacy of Induction Therapy with High-Dose Interferon for Patients with Hemophilia and Human Immunodeficiency Virus-Hepatitis C Coinfection," was published in Clinical Infectious Diseases (2002;35(12):1527-1533).