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Medical News Bezafibrate Improves Glucose Uptake and Endothelial Function in HIV PatientMarch 28, 2003 A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information! A study from Sweden has found that an HIV-positive patient with lipodystrophy syndrome showed a decline in serum triglycerides along with a significant improvement in glucose uptake following treatment with the drug bezafibrate for three months. "This improvement may be a consequence of the Randle effect, i.e. increased availability of plasma-free fatty acids is negatively correlated to glucose uptake. We also noted a significant improvement in endothelial-dependent flow-mediated dilatation after treatment with bezafibrate. This effect could result from the increased glucose uptake observed and a decrease in insulin resistance secondary to the lowered triglyceride levels by bezafibrate," according to Thomas Nystrom and colleagues at South Stockholm Hospital. The researchers concluded that, "bezafibrate may be of clinical utility in the lipodystrophy syndrome, through its beneficial effects on insulin resistance, glucose uptake and endothelial dysfunction." The study, "Bezafibrate-Induced Improvement in Glucose Uptake and Endothelial Function in Protease Inhibitor-Associated Insulin Resistance," appeared in the Journal of Internal Medicine (2002;252(6):570-574). Drug Week 02.14.03 A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!  This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
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