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Side Effects Reported with Approved Anti-HIV Drugs

Spring 2000

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Protease Inhibitors

amprenavir (Agenerase)

Diarrhea, nausea, vomiting, intestinal gas, abdominal pain, headache, dizziness, mental depression, altered taste sensations, mouth rash, skin rash, paresthesias around the mouth, elevated liver enzymes, elevated blood glucose, diabetes, elevated triglycerides, elevated cholesterol, body fat redistribution


indinavir (Crixivan)

Diarrhea, nausea, vomiting, abdominal pain, acid reflux, loss of appetite, headache, dizziness, fatigue, insomnia, muscle pain, dehydration, dry mouth, dry skin, skin rash, ingrown toenails, altered taste sensations, elevated liver enzymes, elevated bilirubin, elevated triglycerides, elevated blood glucose, diabetes, body fat redistribution

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Special concerns: kidney stones (indicated by flank and/or groin pain), hemolytic anemia, liver failure


nelfinavir (Viracept)

Diarrhea, nausea, intestinal gas, abdominal pain, fatigue, skin rash, elevated liver enzymes, elevated creatinine, elevated blood glucose, diabetes, elevated triglycerides, body fat redistribution


ritonavir (Norvir)

Diarrhea, nausea, vomiting, acid reflux, abdominal pain, loss of appetite, headache, dizziness, weakness, fatigue, insomnia, paresthesias (especially around the mouth), altered taste sensations, muscle pain, numbness, skin rash, elevated liver enzymes, elevated creatinine, elevated blood glucose, diabetes, elevated triglycerides, elevated cholesterol, body fat redistribution

Special concerns: hypersensitivity reaction, liver failure


saquinavir (Invirase or Fortovase)

Diarrhea, nausea, acid reflux, intestinal gas, abdominal pain, fatigue, mental depression, skin rash, elevated liver enzymes, elevated creatinine, elevated blood glucose, diabetes, elevated triglycerides, body fat redistribution


Nucleoside Analogs

AZT (Retrovir)

Diarrhea, nausea, abdominal cramps, loss of appetite, fever, headache, insomnia, dizziness, fatigue, muscle and joint pain, myopathy, skin rash, altered taste sensations, elevated liver enzymes

Special concerns: hematologic toxicity -- bone marrow suppression, anemia, low white cell counts


ddC (Hivid)

Diarrhea, nausea, vomiting, abdominal pain, fever, headache, fatigue, skin rash, mouth ulcers, peripheral neuropathy, muscle pain, elevated amylase, elevated liver enzymes, anemia, low white cell counts

Special concerns: pancreatitis


ddI (Videx)

Diarrhea, nausea, vomiting, abdominal pain, weight loss, fever, chills, headache, fatigue, skin rash, dry eyes and mouth, mouth ulcers, peripheral neuropathy, muscle and joint pain, altered taste sensations, elevated liver enzymes, elevated creatinine, elevated amylase, elevated triglycerides, low white cell counts

Special concerns: pancreatitis, retinal lesions in children


d4T (Zerit)

Diarrhea, constipation, nausea, vomiting, abdominal pain, loss of appetite, fever, chills, malaise, headache, dizziness, fatigue, insomnia, mental depression, skin rash, dry skin, peripheral neuropathy, muscle and joint pain, elevated liver enzymes, elevated amylase, anemia, low white cell counts


3TC (Epivir)

Diarrhea, nausea, abdominal pain, loss of appetite, fever, chills, malaise, headache, dizziness, fatigue, insomnia, mental depression, skin rash, peripheral neuropathy, muscle and joint pain, hair loss, low white cell counts

Special concerns: pancreatitis, especially in children


abacavir (Ziagen)

Diarrhea, nausea, vomiting, loss of appetite, fever, headache, fatigue, insomnia, skin rash, mouth ulcers, muscle and joint pain, elevated liver enzymes, elevated creatinine

Special concerns: potentially fatal hypersensitivity reaction characterized by flu-like symptoms, sore throat, cough, shortness of breath, and measles-like rash


Non-Nucleoside Reverse Transcriptase Inhibitors

delavirdine (Rescriptor)

Diarrhea, nausea, headache, fatigue, skin rash, elevated liver enzymes

Special concerns: Stevens-Johnson syndrome


nevirapine (Viramune)

Nausea, fever, headache, skin rash, elevated liver enzymes, low white cell counts

Special concerns: Stevens-Johnson syndrome


efavirenz (Sustiva)

Diarrhea, nausea, headache, dizziness, malaise, fatigue, insomnia, mental anxiety, inability to concentrate, unusual dreams, nightmares, hallucinations, skin rash, elevated liver enzymes

Special concerns: may cause birth defects

Related BETA Article: Adverse Effects Associated with Antiretroviral Therapy


Back to the SFAF BETA Spring, 2000 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
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This article was provided by San Francisco AIDS Foundation. It is a part of the publication Bulletin of Experimental Treatments for AIDS. Visit San Francisco AIDS Foundation's Web site to find out more about their activities, publications and services.
 
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Side Effect Chart: An Abbreviated, At-a-Glance Guide to HIV Drug Side Effects
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