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Medical News New Vulnerability Found in AIDS Virus, German Scientists SayAugust 3, 2005 A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information! On July 24, a team led by Hans-Georg Kraeusslich, a virology professor at Heidelberg University Hospital, announced it had successfully used a fragment of protein known as a peptide to halt assembly of the shell of HIV. The virus is unable to reproduce unless the membrane is complete. The peptide functioned in a test tube but cannot be used directly as a drug, because infected cells do not accept it. Nevertheless, the scientists hope to discover other, more viable substances with a similar function. When HIV spreads from an infected cell, it remains incomplete. The peptide, called a capsid assembly inhibitor, docks onto part of the membrane of the immature HIV and prevents it from developing a mature shell, the capsid. The researchers published their report, "A Peptide Inhibitor of HIV-1 Assembly In Vitro" online in Nature Structural and Molecular Biology (07.24.05;doi:10.1038/nsmb964). Deutsche Presse-Agentur 07.26.05 A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!  This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
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