Reinfections, Persistent Infections, and New Infections After General Population Screening for Chlamydia Trachomatis Infection in The Netherlands
October 21, 2005
The authors conducted a cross-sectional study among a subsample of participants in a population-based screening in urban and rural areas of the Netherlands to determine the rate of new infections, reinfections or persistent infections with Chlamydia trachomatis; to define appropriate screening intervals; and to identify risk factors for reinfection.
A group of 21,000 15- to 29-year-old women and men were offered home-based urine chlamydia testing. One year after the study, a subsample of 299 participants were offered retesting.
The researchers studied the rate of infection with C. trachomatis, using serovar determination to potentially discriminate between new infections and reinfections or persistent infections. They found nine C. trachomatis infections among 187 respondents (4.8 percent confidence interval, 1.7-7.9). Prevalence was 10.4 percent (5 of 48) in previous positives and 2.9 percent (4 of 139) in negatives. Three of 5 repeatedly positive participants were infected with a different C. trachomatis serovar.
"Our study indicates that infected persons found in a systematic, population-based screening should be rescreened within 1 year," the investigators concluded. "Optimal screening intervals still need to be determined."
Sexually Transmitted Diseases
10.05.2005; Vol. 32; No. 10: P. 599-604; Irene K. Veldhuijzen, M.Sc.; Jan E.A.M. Van Bergen, M.D., M.P.H.; Hannelore M. Gotz, M.D., M.P.H.; Christian J.P.A. Hoebe, M.D., Ph.D.; Servaas A. Morre, Ph.D.; Jan Hendrik Richardus, M.D., Ph.D.; for the PILOT CT Study Group
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