Persistence of Human Papillomavirus Infection Is Linked to Chlamydia
September 28, 2005
"Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known," I. Sillins and colleagues at Lund University explained in the current study.
To investigate whether Chlamydia trachomatis infection is a risk factor for HPV persistence, the authors studied a cohort of 12,527 women participating in a population-based HPV screening trial in Sweden. Of these, 6,418 women completed HPV DNA testing by general primer PCR and typing by reverse dot blot hybridization.
"On average 19 months later, 303 women that had been HPV-positive and had normal cytology at enrollment completed a new HPV test," the authors reported. Participants were given an 87-item questionnaire to test for environmental exposures, and previous sexually transmitted infections were investigated by serology. Forty-four percent of the women at follow-up were positive for the same type of HPV DNA as at enrollment.
"Persistence of oncogenic HPV infections is more likely among women with a previous C. trachomatis infection," the researchers concluded.
The full study, "Chlamydia Trachomatis Infection and Persistence of Human Papillomavirus," was published in the International Journal of Cancer (2005;116(1):110-115).
Women's Health Weekly
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.