Herpes Simplex Virus Type 2 (HSV-2) Seroprevalence at the Time of HIV-1 Diagnosis and Seroincidence After HIV-1 Diagnosis in an Ethnically Diverse Cohort of HIV-1-Infected Persons
April 17, 2006
Researchers in the current study sought to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence one year or more after HIV diagnosis.
HSV type-specific antibodies were detected using enzyme immunoassay in a cohort of 850 adults diagnosed with HIV in 1986-2001 and followed for a median of three years. HSV-2 seroprevalence was 63 percent (95 percent confidence interval [CI], 60-66 percent) and was associated with female gender, black ethnicity, heterosexual risk group, and older age. HSV-2 seroincidence was 1.8 per 100 person-years (95 percent CI, 0.8-2.8) and was associated with other sexually transmitted diseases, including gonorrhea (P=0.05) and human papillomavirus (P=0.005). Twenty-one percent of HSV-2-seropositive persons were diagnosed with genital herpes, which was more likely in persons who tested HIV-positive prior to 1997 (adjusted odds ratio, 5.11; 95 percent CI, 3.28-7.98; P=0.0001).
"Results confirm the epidemiologic association between HIV-1 and HSV-2. HSV-2 seroconversion was a marker of high-risk sexual behavior. The likelihood of developing symptoms of genital herpes declined from 1997 onward," the researchers concluded.
Sexually Transmitted Diseases
02.06; Vol. 33; No. 2: P. 96-101; Meghna Ramaswamy, B.Sc.; Caroline Sabin, Ph.D.; Candice McDonald, M.D.; Melvyn Smith, Ph.D.; Chris Taylor, M.D.; Anna Maria Geretti, M.D., Ph.D.
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.