Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014
  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

New Safety Warning For Liquid Amprenavir

May 5, 2000

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!


"Certain ethnic populations (Asians, Eskimos, Native Americans) and women may be at increased risk of adverse events from the liquid formulation of Amprenavir."


New concerns about the possibility of severe side effects related to the use of the liquid formulation of the protease inhibitor, amprenavir (Agenerase), has prompted the manufacturer Glaxo Wellcome to issue a letter outlining the safety concerns.

Of concern is the large amount of propylene glycol contained in liquid Agenerase. Propylene glycol is added to Agenerase to help the drug dissolve more easily. Propylene glycol is difficult for some people to metabolize and can accumulate -- increasing the risk of adverse events. Glaxo Wellcome has changed the labeling information that will be included with Agenerase to address the potential safety concerns.

In the letter sent to providers, Glaxo Wellcome stated that, "ANGENERASE Oral Solution is contraindicated in infants and children below the age of four years, pregnant women, patients with hepatic or renal failure, and patients treated with disulfiram or metronidazole." The letter also warned that "certain ethnic populations (Asians, Eskimos, Native Americans) and women may be at increased risk" of adverse events.

Advertisement
Glaxo Wellcome also recommend that people taking the liquid Agenerase be closely monitored for the following adverse events "seizures, stupor, tachycardia, hyperosmolality, lactic acidosis, renal toxicity and hemolysis." The use of alcoholic beverages should also be avoided by anyone taking the liquid form of Agenerase.


A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by Seattle Treatment Education Project. It is a part of the publication STEP Ezine.
 
See Also
More on HIV Medications
More News on Amprenavir (Agenerase)

Tools
 

Advertisement