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Know Your HIV Drugs: Protease Inhibitors

This is the final installment of our three-part series on antiretroviral drugs. Food and Drug Administration (FDA) approval of the first protease inhibitors (PIs) in April, 1996 marked a turning point in the fight against HIV. AIDS-related deaths dropped dramatically in subsequent years and many people experienced dramatic recoveries in health as a result of PIs. However, PIs always brought many side effects, and the long-term implications of these side effects is still undetermined. In this issue we will review each of the FDA drugs currently approved in this class of antiretrovirals, including a brief description of the common side effects associated with each drug.


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