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Insulin Resistance in HIV Lipodystrophy Syndrome

March 12, 2001

Researchers recently completed a study identifying the incidence of insulin resistance in HIV-patients who exhibit signs of lipodystrophy. The authors noted two significant metabolic changes occurring in those patients, including significant insulin resistance and hyperlipidemia linked to fat redistribution. The characteristic bunching of metabolic abnormalities, as exhibited by fasting hyperinsulinemia in relationship to normal fasting glucose levels, results in a high insulin resistance condition and may also place HIV-infected lipodystrophy patients at a higher risk for cardiovascular disease (CVD). Another significant factor for CVD risk is the weight gain associated with HIV-related lipodystrophy and insulin resistance. There are insulin-sensitizing drug compounds currently being used to combat the metabolic changes brought on by the condition, but further clinical trials are recommended to determine the long-term effects of the treatment. The researchers feel that until more is understood about the condition, clinicians should recommend a treatment program based on modified diet, exercise, and weight management for patients with HIV-associated lipodystrophy.


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Insulin Resistance in HIV Lipodystrophy Syndrome


Adapted from:
AIDS Clinical Care
02/01 Vol. 13, No. 2, P. 1; Hadigan, Colleen; Grinspoon, Steven


  
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This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
 
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