The articles in this issue of the STEP Perspective were written in response to information from the Governor's Advisory Council on HIV/AIDS (GACHA) meetings, as well as in the popular press, that demonstrates a rising impact of HIV/AIDS in communities of color, among women and youth, and in rural areas. The epidemic is changing and communities must respond. There will be no one magic bullet. Instead, there must be multiple, flexible approaches to preventing HIV and to providing care and services to those living with HIV and AIDS.