In 2001, 20 counties and one city accounted for 50.6 percent of all reported primary and secondary syphilis cases in the United States. Following are those locations, their number of reported syphilis cases, and the rate of cases per 100,000 population.

1. Wayne County, Mich. (Detroit) 379; 18.4/100,000. 2. Cook County, Ill. (Chicago) 339; 6.3/100,000. 3. Fulton County, Ga. (Atlanta) 224; 27.5/100,000. 4. Los Angeles County, Calif. (Los Angeles) 211; 2.2/100,000. 5. Shelby County, Tenn. (Memphis) 208; 23.2/100,000. 6. Dade County, Fla. (Miami) 185; 8.2/100,000. 7. Baltimore, Md. 161; 24.7/100,000. 8. Maricopa County, Ariz. (Phoenix) 148; 4.8/100,000. 9. New York County, N.Y. (New York City) 145; 9.4/100,000. 10. San Francisco County, Calif. (San Francisco) 138; 17.8/100,000. 11. Marion County, Ind. (Indianapolis) 128; 14.9/100,000. 12. Dallas County, Texas (Dallas) 121; 5.5/100,000. 13. Harris County, Texas (Houston) 103; 3.0/100,000. 14. Robeson County, N.C. 90; 73.0/100,000. 15. Essex County, N.J. (Newark) 79; 10.0/100,000. 16. Philadelphia County, Pa. (Philadelphia) 78; 5.1/100,000. 17. Davidson County, Tenn. (Nashville) 76; 13.3/100,000. 18. Bexar County, Texas (San Antonio) 71; 5.1/100,000. 19. Kings County, N.Y. (New York City) 71; 2.9/100,000 20. Guilford County, N.C. (Greensboro) 70; 16.6/100,000. 21. Franklin County, Ohio (Columbus) 62; 5.8/100,000.

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