Public Health Service Guidelines for the Management of Health-Care Worker Exposures to HIV and Recommendations for Postexposure Prophylaxis

Health-care providers in the United States are encouraged to enroll HCWs who receive PEP in a confidential registry developed by CDC, Glaxo Wellcome Inc., and Merck & Co., Inc., to assess toxicity; telephone (888) 737-4448 ([888] PEP-4HIV), or write the HIV PEP Registry, 1410 Commonwealth Drive, Suite 215, Wilmington, NC 28405. Unusual or serious and unexpected toxicity from antiretroviral drugs should be reported to the manufacturer and/or FDA, telephone (800) 332-1088.

Health-care providers also should report instances of prenatal exposure to antiretroviral agents to the Antiretroviral Pregnancy Registry. The registry is an epidemiologic project to collect observational, nonexperimental data on antiretroviral drug exposure during pregnancy to assess potential teratogenicity. Referrals should be directed to the Antiretroviral Pregnancy Registry, 1410 Commonwealth Drive, Suite 215, Wilmington, NC 28405; telephone (800) 258-4263 or (800) 722-9292, ext. 39437; fax (800) 800-1052.

A protocol has been developed to evaluate HIV seroconversion in an HCW who received PEP. These events can be reported to CDC, telephone (404) 639-6425.