June 21, 2007
Tuberculosis (TB) is a disease caused by a germ called Mycobacterium (my-ko-bak-TEER-I-um) tuberculosis. TB most often affects the lungs, but TB germs can infect any part of the body. TB may be latent or active TB. "Latent" means that the germs are in the person's body but are not causing illness. If you have latent TB you will not have symptoms and cannot spread TB. However, if HIV has made your immune system too weak to stop the TB germs from growing, they can multiply and cause active TB (also called TB disease).
In people with HIV, TB in the lungs or anywhere else in the body is called an AIDS-defining condition. In other words, a person with both HIV and active TB has AIDS.
TB is spread from one person to another through the air. When a person who has TB disease of the lung or throat coughs, sneezes, or sings, TB germs may be sent into the air. A person who breathes air that contains these germs may get TB. People with TB disease are most likely to spread it to people they spend time with every day, such as family members, friends, or coworkers.
You can't get TB from shaking hands, sitting on a toilet seat, or sharing dishes or utensils.
Some activities and jobs may increase your chances of spending time with people who have TB and getting TB. These include working in a health care setting (a hospital, a clinic, a doctor's office), in jails and prisons, and in shelters for homeless people. You and your doctor should decide whether you should be working in such a place. If you do things that may increase your chances of getting TB, you and your doctor may decide that you need to be tested for TB more often than once a year.
If you can, avoid spending time with someone who has active TB but is not taking medicine or has just started taking medicine. A person who has been taking medicine for a few weeks can usually no longer spread TB to you. That person's doctor will say when it's safe for other people to spend time with him or her.
If you are exposed to a person with active TB, you should ask your doctor about getting treatment, even if your skin test was negative for TB.
Your symptoms depend on where in your body the TB germs are growing. TB germs usually grow in the lungs. TB in the lungs may cause:
Other symptoms are:
No. Active TB most often affects the lungs. But it can also affect almost any other body organ, such as the kidneys or the spine. A person whose TB is not in the lungs or throat usually cannot give TB to other people.
Yes. Latent TB is much more likely to become active TB in someone with HIV. This is because HIV weakens the immune system, which makes it harder for the body to fight off diseases like TB.
Yes. If you have not already had TB or a positive result from a skin test for TB in the past, get a tuberculin skin test, or TST at the health department or your doctor's office.When you have the test, a health care worker will inject a small amount of testing fluid just under the skin on the lower part of your arm. After 2 or 3 days, the health care worker will check your arm to see whether you had a positive reaction to the test. If you have a positive test result (which usually means you have latent TB), you may need other tests to see whether you have TB disease (active TB). These tests usually include a chest x-ray and a test of the phlegm you cough up. Because TB can grow somewhere else in your body, other tests may be done. If you have a negative test result you should be tested again at least once a year, depending on your chances of getting TB. Discuss your chances of getting TB with your doctor. If you are an HIV-infected mother whose baby was born after you got HIV, have your baby tested for TB when the baby is 9 to 12 months old.
Yes. The drug isoniazid can help prevent latent TB from becoming active TB. People with HIV infection who need to take isoniazid are also given a vitamin called pyridoxine to prevent peripheral neuropathy (a disorder of the nervous system).
Get tested for latent TB, with a TST, as soon as possible after you learn you have HIV. If your skin test result is positive (but you do not have active TB), you will most likely be given 9 months of treatment with isoniazid to prevent active TB. You need to take your medicine for the full 9 months because TB germs die very slowly. Take your medicine exactly as your doctor or nurse tells you.
If you are a woman who is pregnant, you may still take isoniazid to fight TB. However, your doctor may tell you not to take the medicine until 3 months after delivery.
The germs that caused your latent TB might not be killed by isoniazid. In that case, you will be given another drug (probably rifampin) or a combination of drugs used to prevent TB.
Yes. The drugs that fight TB work as well in people with HIV as they do in people who do not have HIV.
Several drugs are used to treat active TB. You will need to take more than one drug for several months. Your symptoms may go away within a few weeks after you start taking the medicine. TB germs die very slowly, so you need to keep taking your medicine exactly as your doctor or nurse tells you (the right amount at the right time for the right length of time).
Yes. If you have TB disease of the lungs or throat, you can probably spread TB to other people. You may need to stay home from work or school or other activities for a few weeks. After you've taken your medicine for a few weeks, you will probably no longer be able to spread TB to others, but you need to continue taking your medicine for 6 to 9 months to be totally cured. Your doctor or nurse will tell you when you can return to work or school or other activities. The medicine should not affect your strength, your sexual function, or your ability to work. Taking the medicine as prescribed will keep you from again becoming sick with TB disease.
Yes. But you should know that medicines for TB and the protease inhibitors affect each other. Your doctor will decide which combination of medicines will work best for you.
When TB germs are not killed by a certain drug, that TB is called "drug-resistant." TB germs may become resistant when patients do not take their medicine long enough or in the right amount at the right times. Follow your doctor's advice when taking medicines.People who have drug-resistant TB can transmit it to others. Drug-resistant TB is found often in people who come from areas where TB is common (for example, Africa, Southeast Asia, Latin America) but it also occurs in parts of the United States. When at least two of the best anti-TB drugs (isoniazid and rifampin) can't kill TB germs, the TB is called "multidrug-resistant" TB (MDR TB). A more serious form of MDR TB -- "extensively drug resistant TB" (XDR TB) -- is a relatively rare type of TB that is resistant to nearly all of the most effective medicines used to treat TB. A patient with MDR or XDR TB may need to see a doctor who is an expert on drug-resistant TB and who can recommend the best combination of drugs to fight the germs.
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Additional brochures in the Opportunisitic Infections Series: