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Entry Inhibitors: Hope On The Horizon?

October 2004

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Entry. It's what must happen for HIV to infect cells. Blocking HIV entry means the virus does not get inside the T cell. The only approved medication that does this is Fuzeon, which must be injected into the skin twice daily. Even so, other HIV medications must be taken at the same time or else HIV becomes resistant to Fuzeon very quickly. So, what if there were other entry inhibitors? What if they could be combined together to block HIV entry and not allow resistance to develop as quickly? This may be possible in a few years if several new drugs now being studied turn out to be safe and effective. The entry inhibitor "pipeline" for treating HIV has just become more promising.

Although the drug candidates listed still have at least 3 to 5 years of more study ahead, some may eventually become new options for people with HIV/AIDS. These agents work in different ways: some bind to parts of HIV, while others bind to parts of the T cell that HIV needs for entering the cell. Plus, some people think these drugs may have fewer overall side effects because they work outside of the T cells, unlike current medications that work inside of the cells. But, it's way too early to say that for sure. Keep your fingers crossed and read upcoming issues of HIV Treatment ALERTS! for further updates!


HIV Entry Inhibitors in Early Development
Drug Name
Currently given
Company
AMD-070By mouthAnormed
AMD-887By mouthAnormed
PRO-140By injection or infusion*Progenics
BMS-488043By mouthBristol-Myers Squibb
UK 427,857By mouthPfizer
SP-01ABy mouthSamaritan Pharmaceuticals
SCH-DBy mouthSchering Plough
TNX-355By infusion*Tanox
GSK(GW)-873140By mouthGlaxoSmithKline
PRO-542By injection or infusion*Progenics
* Infusion is when medication is given directly into a vein over a period of time.


Back to the HIV Treatment ALERTS! October 2004 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
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This article was provided by The Center for AIDS. It is a part of the publication HIV Treatment ALERTS!. Visit CFA's website to find out more about their activities and publications.
 
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More on HIV Medications
More on Entry Inhibitors in Development

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