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By Michael Marco and Martin Majchrowicz

July 25, 1994

  1. The Countdown 18 Months Plan. Written by Jason Childers, Chris DeBlasio, Garance Franke-Ruta, Jerry Jontz, Derek Link, Rich Lynn, Kim Powers and Scott Slutsky. Treatment + Data Committee, ACT UP/New York, November 1990.

  2. For example, Klimas et al (Klimas 1993) define a PR as "an overall reduction of greater that or equal to 25% in tumor load."

  3. Rad is a unit of energy absorbed from ionizing radiation. Gy, which is short for Gray, is the clinical dosing term for used radiation treatment.

  4. ACTG 006 was conducted before the ACTG response criteria for KS were adopted and relied on "standard" oncologic response criteria. Many of the "minor" responses would have been considered PRs had the revised, KS-specific criteria been used (Fischl 1993).

  5. Chemotherapy generally has to be continued in responding patients, or the KS regrows. This brings up the issue of the need for maintenance therapy for those who cannot -- for many reasons -- continue on chemotherapy.

  6. Intermittent claudication, also known as Charcot's syndrome, is a cramping pain that is caused by an inadequate supply of blood to the affected muscles.

  7. Both Yiddish words, tsuris=pity/shame and mishigos=craziness.

  8. Harrington M: 9th AIDS Clinical Trials Group (ACTG) Meeting , 1990 (Unpublished).

  9. ACTG 110, 142 and 149.

  10. As one prominent AIDS oncologist remarked, "People with good training in oncology can certainly learn how to care for cancers in AIDS patients -- none of us were trained to be an 'AIDS oncologist'."

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