Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  Breaking News: FDA Approves Triumeq, New Once-Daily Combination Pill
  
  • Email Email
  • Glossary Glossary
The Body Covers: The XIII International AIDS Conference
The Combination of Ritonavir and Amprenavir in Salvage Regimens Overcomes Clinically Multiple-Drug-Resistant HIV

July 12, 2000

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

  • The combination of ritonavir and amprenavir in salvage regimens overcomes clinically multiple-drug-resistant HIV (Poster, WePeB4204)
    Authored by R. Hsu, P.C. Bellman (United States)


Studies such as GART and VIRA3001 have showed us that amprenavir is probably the protease inhibitor with more "residual" activity after the failure of other protease inhibitors. In this study, a retrospective review of 30 multi-drug resistant patients treated with amprenavir 1200mg Bid and ritonavir 200mg Bid was presented. After a median follow up of 27 weeks, 50% of the patients had less than 400 copies of HIV RNA. The regimen is well-tolerated metabolically -- with only 10% cholesterol elevations and 20% triglyceride elevations. I think this particular regimen includes too many pills (10 pills twice a day, plus a chosen background regimen). The difficulty of tolerability might even have biased the study against the combination. The bottom line is that, in the case of multi-drug resistance, amprenavir is often the last feasible option.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

See Also
More Third Line/Rescue HIV Treatment Research



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement