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The Body Covers: The XIII International AIDS Conference
Emergence of Drug Resistance in the Treatment-Naive Population
July 12, 2000 This article is part of TheBody.com's archive. Because it contains information that may no longer be accurate, this article should only be considered a historical document.
Transmission of drug-resistant HIV-1 in San Francisco (Poster, WePpB1304)In this study, researchers completed genotype and phenotype testing on 118 patients seen at San Francisco General Hospital within 12 months of seroconversion between 1996 and 1999. They described a declining prevalence of NRTI resistance along with a rising prevalence of resistance to NNRTIs and PIs during this time. Overall, genotypic resistance to NRTIs was seen in 8.5% of patients. Phenotypic resistance to PIs was 6.5%. Though not rising to alarming levels, this degree of primary antiretroviral resistance is certainly cause for concern.
Epidemiologic surveillance of HIV resistance from 1994 to 1999; increasing frequency of naive patient mutants (Poster, WePpB1306)In this study, RT mutations were investigated in 32 recent seroconverters from the mid-1990s until 1999. Though the numbers are small, from year to year an increase in non-wild-type (i.e., strains with mutations) isolates did occur during this time. Three of seven recent seroconverters in 1999 had NRTI-associated resistance mutations: one had a 184 mutation, one other had 41/215 and another had 41/184/215 mutations. This demonstrates the presence of primary antiretroviral resistance in Italy (as well as in the U.S., as in the earlier paper from San Francisco).This article is part of TheBody.com's archive. Because it contains information that may no longer be accurate, this article should only be considered a historical document.
This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.
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