The Body Covers: The XIII International AIDS Conference
Post-Exposure Prophylaxis (PEP)
July 11, 2000
Benais and colleagues reviewed current experience with the use of PEP for victims of sexual assault in Paris. These authors described a program that has been in place since June 1999 that provides antiretroviral therapy to sexual assault victims if they present within 48 hours of the attack. Due to concerns about possible AZT resistance in the population, this group chose to use a three-drug combination of ddi, D4T, and nelfinavir. Treatment is continued for 30 days and the clinical evaluations and laboratory tests are performed on days 0, 2, 15, 30 and 60. This PEP regimen was used in 100 patients in the past year. Two perpetrators were known to be HIV-positive, the rest were of unknown status. One quarter of the patients who received PEP never returned for follow-up. No cases of HIV seroconversion were identified. The regimen was safe and well-tolerated without evidence for toxicity during laboratory monitoring. While this study is too small to document the efficacy of PEP, the safety of the regimen is encouraging. The authors concluded that they plan to continue this program. These results suggest that programs can be put in place to make PEP available to treat exposures that occur outside the health care setting.
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