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The Body Covers: The XIII International AIDS Conference
Nelfinavir vs. Indinavir

July 12, 2000

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

  • Long-term comparative outcomes of indinavir (IDV) vs. nelfinavir (NFV)-based HAART in naive patients in routine clinical practice (Poster, WePeB4142)
    Authored by M.J. Pérez-Elías, A. Moreno, J.L. Casado, V. Muñoz, A. Antela, F. Dronda, L. Moreno, S. Moreno (Spain)


There has as yet not been a randomized study comparing nelfinavir to indinavir. Given that indinavir, when given without ritonavir, is taken every eight hours, it is considered a more challenging medication to comply with. This study explored the outcomes in a group of patients who were given one of these two protease inhibitors (PIs) in combination with nucleoside antivirals. Researchers in Madrid (Spain) did the study. They reported their findings on 134 people, 90 who were on indinavir, and 44 who were on nelfinavir.

Overall at one year, there were similar success rates at achieving a viral load below 50 copies (both around 90%). However, at about two years of follow-up, significantly more of the people followed were still on nelfinavir (70%) versus on indinavir (45%). This study supports much of the work that has been done in the past few years to make indinavir an easier drug to take, including adding some dose of ritonavir which allows it to be taken just twice a day.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

See Also
More on HIV Medications
More Research on Nelfinavir (Viracept)



  
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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