The Body Covers: The 7th European Conference on Clinical Aspects and Treatment of HIV-Infection
Improved Tolerability and Adherence with Reduced Mass Didanosine Tablets in HIV-1 Infected Adults Receiving Highly Active Antiretroviral Therapy
Authored by A. Harling, S. Doshi, H. Leake, et al.
Recently , the FDA in the US has approved a new formulation of ddI (also known as Videx or didanosine). While the drug can be very successful, it is one of the antivirals that is less well tolerated by some due to the need to package it with an antacid buffer. In this study, researchers compared the new reduced mass ddI tablets (200 mg) with the prior formulation, which is usually given as 100 mg tablets. The reduced mass tablets allow for once daily dosing with two tablets compared to four tablets with the older preparation. (The success of once a day ddI compared to its use in the standard twice a day approach has been seen in several studies.)
Of 76 participants, 73 (96%) reported that they preferred taking the new formulation. Two had no preference and one actually preferred the original 100 mg tablets. The following improvements in side effects were reported:
This study may be useful information for those now on ddI who are doing well in terms of viral control, but not tolerating this formulation of the drug. This study showed that the reduced-mass ddI tablet may decrease the usual side effects of ddI, which may increase someone's willingness to stay on the medication and the overall success of any regimen.
This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.