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The Body Covers: The 39th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy
Poster Session 89-F: Novel Antiretroviral Agents

September 27, 1999

These two abstracts describe a novel new nonnucleoside reverse transcriptase inhibitor (NNRTI) which currently goes by the name SJ-3366. It appears to have significant activity against both HIV-1 (the dominant strain of HIV in North America and Europe) as well as HIV-2 (more common in parts of Africa). Importantly, the investigators report the virus has two ways of working against HIV, unlike any of the other drugs in this class. First, it inhibits reverse transcriptase in HIV-1 virus, an enzyme that AZT and similar drugs also block. However, SJ-3366 also appears to block the attachment of both HIV-1 and also HIV-2 to human T-cells. Because it may work against the HIV-1 virus in more than one way, unlike other drugs of this type, it is a promising and potentially important new member of the NNRTI class.

Like most other NNRTI's, this compound looses activity when typical mutations are present. Other studies showed there may be increased activity when used with ddI, and it appears to also work well with other HIV drugs in lab tests. These reports are promising and deserve further study.

Abstract: A Highly Potent NNRTI Possessing Potential Dual Activity Against HIV-1 Reverse Transcriptase I and Chemokine Receptor Interactions (Paper 925)
Authored by: C. Lackman-Smith, et al.

Abstract: Therapeutic Potential of a New Nonnucleoside Reverse Transcriptase Inhibitor of HIV-1 with Activity Against HIV-2 (Paper 926)
Authored by: R. W. Buckheit, et al.



  
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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