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The Body Covers: The 39th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy
Slide Session 66.A: Drug Interactions in HIV Therapy

Coverage provided by Howard Grossman, M.D.

September 27, 1999

The package insert for indinavir warns that grapefruit juice, which contains substances that inhibit cytochrome 3A4 in the gastric mucosa, may increase indinavir levels.

This study used 15 HIV+ patients taking indinavir, but no other medications suspected to influence P450 3A4. 14 patients had normal gastric pH (derived by the use of a swallowed radiotransmitter device) and 1 was hypoacidic. Subjects were given a doubly concentrated dose of grapefruit juice or water.

Gastric acidity was increased (decreased pH), which may delay absorption of indinavir. However, the Tmax of indinavir was prolonged, but there were no other changes in pharmakokinetic values.

Abstract: Grapefruit Juice Increases Gastric pH, but Does Not Affect Indinavir (IDV) Exposure, in HIV Patients (Paper 660)
Authored by: M. J. Shelton, H. Wynn, et al.



  
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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