The Body Covers: The 39th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy
Slide Session 66.A: Drug Interactions in HIV Therapy
September 27, 1999
The package insert for indinavir warns that grapefruit juice, which contains substances that inhibit cytochrome 3A4 in the gastric mucosa, may increase indinavir levels.Abstract: Grapefruit Juice Increases Gastric pH, but Does Not Affect Indinavir (IDV) Exposure, in HIV Patients (Paper 660)
This study used 15 HIV+ patients taking indinavir, but no other medications suspected to influence P450 3A4. 14 patients had normal gastric pH (derived by the use of a swallowed radiotransmitter device) and 1 was hypoacidic. Subjects were given a doubly concentrated dose of grapefruit juice or water.
Gastric acidity was increased (decreased pH), which may delay absorption of indinavir. However, the Tmax of indinavir was prolonged, but there were no other changes in pharmakokinetic values.
Authored by: M. J. Shelton, H. Wynn, et al.
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