Slide Session 66.A: Drug Interactions in HIV Therapy

The Body Covers: The 39th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy

Slide Session 66.A: Drug Interactions in HIV Therapy

Coverage provided by Howard Grossman, M.D.

September 27, 1999

Tipranavir, formerly PNU-140690 is a nonpeptidic HIV protease inhibitor that is active in vitro against highly resistant viruses. It was tested in 23 healthy volunteers in theses studies.

Tipranavir is a potent inducer of CYP 3A and a P glycoprotein substrate. It induces a significant increase in ritonavir metabolism, with an 80-88% reduction in AUC and a decrease in half-life and peak levels. There is a 20-fold decrease in trough levels (Cmin).

On the other hand, ritonavir causes a marked rise in all PK parameters of tipranavir, with an increase in AUC of 12 fold and an increase of Cmin of 45 fold.

The second study reported here showed that even a low dose of ritonavir could produce this effect with tipranavir.

It appears that Pharmacia & Upjohn, the manufacturer of tipranavir, is already talking to Abbott about producing a combination pill to improve the pharmakokinetics of tipranavir.

Abstract: Pharmacokinetic (PK) Interaction between the HIV Protease Inhibitors Tipranavir and Ritonavir (Paper 657)
Authored by: J. R. Baldwin, et al.

Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

The Body is a service of Remedy Health Media, LLC, 250 West 57th Street, New York, NY 10107. The Body and its logos are trademarks of Remedy Health Media, LLC, and its subsidiaries, which owns the copyright of The Body's homepage, topic pages, page designs and HTML code. General Disclaimer: The Body is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.