Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014
  
  • Email Email
  • Glossary Glossary
The Body Covers: The 35th Annual Meeting of the Infectious Diseases Society of America
Are There Gender Differences in HIV Disease Progression?

November 19, 1999

One of the more surprising findings of the last two years was the observation by Farzadegan et al that HIV-infected women had lower plasma virus RNA levels than men, even after controlling for CD4 count {Farzadegan, Hoover, et al. 1998 ID: 1739} . The implication of these data was that women might experience more rapid disease progression, with lower virus loads leading to greater depletion of CD4 cells than had been observed in men with similar virus loads. The biological basis for these observations is poorly understood.

To further explore this question, Carpenter et al analyzed data from 264 patients with baseline CD4 counts >500/mm3 and at least 48-weeks of follow-up data. Overall, CD4 counts declined at a rate of 40 cells/yr. In a multivariate analysis, baseline plasma HIV-1 RNA and extent of antiviral use were significant predictors of the the CD4 slope. The rate of CD4 cell loss was not associated with gender in this study regardless of baseline HIV-1 RNA level and regardless of antiretroviral therapy.

Although these results may appear to contrast with those of Farzadegan et al., the are not necessarily contradictory. For example, although this study found similar rates of CD4 cell loss in HIV-infected men and women, it remains possible that women lose CD4 cells at lower virus loads than men. However, Carpenter et al found no significant differences between men and women with regard to virus load. Another possible explanation is that some investigators are studying women soon after infection, whereas other investigators are studying cohorts of infected women with a longer duration of HIV-1 infection. A recent longitudinal study of seroconverters found that although women have lower virus loads than men at the time of seroconversion, these differences become less significant over time. Given the conflicting nature of these reports overall it is premature to suggest gender-specific algorithms for initiation of antiretroviral therapy.

Abstract: Are There Gender Differences in HIV Disease Progression? (Abstract 375)
Authored by: C.F. Carpenter, J.C. Keruly, R.E. Chaisson, R.D. Moore



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement