Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  
  • Email Email
  • Glossary Glossary
The Body Covers: The 35th Annual Meeting of the Infectious Diseases Society of America
Effects of Switching from Saquinivir Hard Capsule (SQV-HC) to Saquinivir Soft Gel Capsules (SQV-SGC) or Indinavir (IDV)

September 1997

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Dr. Michael Para of Ohio State University reported on the results of an ACTG trial (#333) which evaluated the effects of switching from saquinavir hard capsules (SQV-HC)(1.8 grams/d) to saquinavir soft gel capsules (SQV-SGC) (7.2 grams/d) or indinavir (IDV) (2.4 grams/d), or continuing the SQV-HC. Otherwise, the patients were maintained on their stable nucleoside RTI combinations. The 72 participants had a mean plasma viral RNA level of 4.3 logs10 copies/ml, and a median CD4 count of 222 cells/mm3, and the median duration of SQV use was 112 weeks. The group that remained on SQV-HC had no significant change in their viral load over the first 6 months, but those who switched to SQV-SGC had a mean viral load decline of 0.4 log10 copies/ml, while those changed to IDV had a mean drop of 0.7 log10 copies/ml. CD4 cells tended to rise more in the group changed to SQV-SGC (mean of 37 cells/mm3) than the IDV group (22 cells/mm3). The data suggest that even after longterm SQV-HC exposure, there are some individuals who will have a virologic benefit from switching to the higher dose of the better absorbed SQV-SGC, or IDV.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

See Also
More on HIV Medications
More Research on Saquinavir (Fortovase, Invirase)
Advertisement:
Find out how a Walgreens specially trained pharmacist can help you



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement