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The Body Covers: The 35th Annual Meeting of the Infectious Diseases Society of America
Safety and Efficacy of Once-Daily Dose of Didanosine (DDI)

September 1997

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Dr. E. Martinez and colleagues from Barcelona, Spain, reported on 80 patients who received ddI once a day, plus D4T 40 mg bid, with or without saquinavir or indinavir. The mean baseline CD4 count was 178 cells/mm3, and the mean plasma viral load was 4.9 logs. Less than 10% of the patients complained about gi side effects or had to withdraw from the study. CD4 counts increased a mean of 86 cells/mm3 and viral load decreased 1.9 logs at 3 months. 43% of patients had peripheral viral loads below 200 copies/ml (all of these were taking a protease inhibitor). The data suggest that daily dosing of ddI is consistent with a good clinical response to combination chemotherapy and deserves further study.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

See Also
More on HIV Medications
More Research on ddI (Didanosine, Videx)



  
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