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The Body Covers: The First International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV
Reaching a Consensus -- Lipodystrophy Case Definition

June 28, 1999

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Chairs: Andrew Carr, Stefan Mauss, and Kathleen Mulligan

Various attendees at this meeting had group discussion sessions on fat wasting, fat accumulation, lipid disturbances, glucose disturbances and miscellaneous manifestations associated with lipodystrophy syndrome in HIV patients. The summaries of these group discussion sessions were presented to all attendees to evolve a lipodystrophy case definition.

The following consensus emerged from the meeting. First, the diagnosis of lipodystrophy in HIV patients should be based on confirmation of patient's self report by the clinician or by clinician's observations alone. Second, the prominent features of fat loss associated with lipodystrophy were buccal (cheek) fat loss, gluteal (buttocks) fat loss and prominent, non-varicose veins in the legs. Fat accumulation can be noted in the trunk resulting in increased abdominal girth. Breast hypertrophy, buffalo hump (on the back of neck), lipomas and increased facial fat can also occur in some patients. These findings are associated with abnormalities in glucose and lipid metabolism.

It was recognized that there might be more that one syndrome of lipodystrophy in HIV patients. There may be other clinical features and laboratory findings of the lipodystrophy syndrome in HIV patients that have not yet been recognized. Further information needs to be collected about the role of gender, age, race, baseline adiposity, types and duration of therapy in development of the lipodystrophy syndrome. A plan was discussed to collect a multitude of data from various sites about the lipodystrophy syndrome in order to come up with a refined definition at a later date.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

See Also
An HIVer's Guide to Metabolic Complications
More Research on Lipodystrophy and Other Metabolic Complications



  
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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