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The Body Covers: The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy Coverage
The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy

September 15, 2000

  • Use of HIV Protease Inhibitors is Associated with Endothelial Dysfunction
    James Stein
  • IMT as Cardiovascular Risk Marker in HIV+ Patients Treated and Untreated with Protease Inhibitors
    Renato Maserati

The presentations for this session were also very good. James Stein from the University of Wisconsin presented data showing that the use of protease inhibitors is associated with endothelial dysfunction. He evaluated flow-mediated vasodilatation of the brachial artery in a cross-sectional analysis of 37 patients using high-resolution ultrasound. Patients on protease inhibitors had impaired FMD, which could be associated with an increased risk of cardiovascular complications down the road. The study was limited in all cross sectional studies. Longitudinal studies, before and after starting treatment, will provide better information, but is an important step in the right direction.

Renato Maserati from Pavia, Italy presented data demonstrating that carotid thickening is present in HAART-treated patients -- which is also a predictor of increased cardiovascular risk. Again, this was a cross-sectional study, which limits its scope, but both studies suggest that one can no longer ignore the cardiovascular risks associated with potent antiretroviral therapy (which was the point that Matthias Egger was making).

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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.