Print this page    •   Back to Web version of article

The Body Covers: The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy Coverage

The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy

Coverage provided by Pablo Tebas, M.D.

September 14, 2000

The best presentation of the afternoon, in my opinion, was from M. Noor from the University of California San Francisco (UCSF) group. They administered indinavir 800 mg q 8h (the usual dose we use in adults) to 10 non-HIV-infected individuals for four weeks and looked carefully at glucose metabolism, lipids and body shape (using fasting glucose, insulin, oral glucose tolerance test, an euglycemic clamp, fasting lipid, and body composition using DEXA and CT). An incredibly intensive study!

They look at the patients twice, both before receiving indinavir and then after four weeks of treatment. In only four weeks they presented evidence that these individuals became insulin resistant and one of them even became a diabetic. Because these patients were not receiving nucleoside analogs, we can be sure that this problem is definitely related to indinavir. There were no changes in lipid metabolism, and body composition remained stable in this short study. These results are in contrast with a previous study with ritonavir that showed severe alterations in lipid metabolism, but no effect in glucose metabolism when given to healthy subjects. So, it looks like not all protease inhibitors are created equal.


This article was provided by Copyright Body Health Resources Corporation. All rights reserved.

You can find this article online by typing the following address into your Web browser:

Please Note: Knowledge about HIV changes rapidly. Note the date of this article's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this article.

General Disclaimer: The Body is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your healthcare provider.