The Body Covers: The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy Coverage
The 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy
September 14, 2000
They look at the patients twice, both before receiving indinavir and then after four weeks of treatment. In only four weeks they presented evidence that these individuals became insulin resistant and one of them even became a diabetic. Because these patients were not receiving nucleoside analogs, we can be sure that this problem is definitely related to indinavir. There were no changes in lipid metabolism, and body composition remained stable in this short study. These results are in contrast with a previous study with ritonavir that showed severe alterations in lipid metabolism, but no effect in glucose metabolism when given to healthy subjects. So, it looks like not all protease inhibitors are created equal.
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