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The Body Covers: The 5th Conference on Retroviruses and Opportunistic Infections
Session 50, Abstract 379: Combination Therapy with AZT + 3TC + Indinavir vs. d4T + 3TC + Indinavir in Pretreated Patients with Less than 200 CD4/mm3

February 3, 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

In this non-randomized study, Dr. Rubio and colleagues looked at the efficacy and tolerance of combination therapy with AZT + 3TC + indinavir as compared to d4T + 3TC + indinavir. They enrolled forty-four pre-treated patients (either AZT and/or ddI and/or ddC, for a median period of just over two years). Patients had fewer than 200 CD4 cells, a viral load of at least 3000 copies/ml, and had never taken a protease inhibitor, d4T, or 3TC. Patient withdrawal because of side effects occurred with equal regularity on each arm (~12%).

Each drug combination proved to be effective, with no statistical difference between the study arms. On the d4T + 3TC + indinavir, which enrolled sixteen patients, the mean baseline CD4 cell count was 79 cells/mm3. By the week 16 point, which was reached by eight patients, the mean CD4 count had risen to 217 cells/mm3, and 7 of the 8 (87%) had achieved undetectable viral loads (<500 copies/ml).

For the twenty-eight patients on the AZT + 3TC + indinavir arm, mean CD4 count at baseline was 52, and had risen to 171 by week 16. Twenty-two patients reached week 16, and 18 of them (82%) were undetectable.

This small study concluded that both regimens have a similar effect in pre-treated patients.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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