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The Body Covers: The 6th Conference on Retroviruses and Opportunistic Infections
Late Breaker No. LB9: High Frequency of Antiretroviral Drug Resistance in HIV-1 from Recently Infected Therapy Naïve Individuals

February 4, 1999

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Understanding the prevalence of transmission of treatment-resistant strains of virus is becoming more important as the HIV epidemic evolves to include a growing number of treated individuals who are healthy and sexually active. Although transmission of virus resistant to all classes of antiretroviral agents has been demonstrated, estimates of the frequency of resistant strains being transmitted to uninfected individuals is unknown. From a therapeutic standpoint, this is very important because complete suppression of HIV replication could be compromised if a newly-infected individual harbors drug-resistant virus.

Wegner and colleagues report seroprevalence of treatment-resistant virus from 114 treatment-naïve adults newly diagnosed among a military population within the last three years. Demographically, men comprise 97% of the group with an age range of 19-45 years (mean of 30), and 46% are Caucasian, while 40% are African American. Using the VircoGENTM system, genotype (presence of gene mutations) was assessed from 95 samples, and phenotype (actual sensitivity to virus as measured in a laboratory setting) from 91 samples. Based upon this reporting schema, genotypic abnormalities were further classified as either possibly resistant or or resistant, while the phenotypic profile was subdivided into intermediate resistant or resistant categories. For the most part, the genotypic profile was able to predict accurately the phenotypic pattern exhibited by virus.


  NRTINNRTI     PI
GenotypeResistance
possible
3%10%8%
 Resistance
evident
1%5%1%
PhenotypeIntermediate
resistance
6%15%0%
 Resistant15%7.7%1%


Aside from demonstrating that mutant strains were frequently transmitted, these data are striking for the predominance of NNRTI resistance. The authors noted further that several different mutations invoking NNRTI resistance were seen in their analysis.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Abstract: High Frequency of Antiretroviral Drug Resistance in HIV-1 from Recently Infected Therapy Naïve Individuals
Authored by: S. Wegner, J. Mascola, A. Barille, N. Aronson, G. Martin, K. Stephan, S. Brodine, S. Tasker, S. Bloor, J. Vingerhoets, K. Hertogs, and B. Larder

See Also
The Body's Guide to HIV Drug Resistance
HIV Mutations



  
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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