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The Body Covers: The 12th International AIDS Conference
Poster Session 42169: Antiviral Effect of AZT versus D4T in Combination with 3TC and Indinavir in the Context of a Population-Based Study

July 2, 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

In addition to this study's 'top-line' finding -- that d4T/3TC/indinavir is as effective as AZT/3TC/indinavir at reducing viral load -- the data presented in this study are significant for two further reasons. First, Dr. Hogg and colleagues have provided further evidence that there is not necessarily any sort of 'magical' synergy between AZT and 3TC. d4T and 3TC can be as potent (and for some patients less toxic) an RTI combination as the well-known AZT/3TC combo. A great deal of data indicating that d4T/3TC is a potent combination when used with a protease inhibitor (in this instance, indinavir) was first presented in Chicago in February at the Retrovirus Conference, and this study confirms the data shown there.

Secondly, this study enrolled 191 patients, all recruited from a Vancouver drug treatment program. Dr. Hogg and his colleagues are to be congratulated for showing that quality clinical trials can be conducted in this population, which is written off by many researchers as too difficult to work with. The team from Vancouver concluded by pointing out the need for prospectively designed trials that are inclusive of all patients with HIV.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Reference

Abstract: Antiviral Effect of AZT versus D4T in Combination with 3TC and Indinavir in the Context of a Population-Based Study
Authored by: Robert Hogg

See Also
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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