Print this page    •   Back to Web version of article

The Body Covers: The 12th International AIDS Conference

Poster Session 22339: A Comparison Between Seminal Plasma RNA and Blood Plasma RNA in HIV+ Men Who Receive Either Zidovudine (ZDV) Plus Lamuvidine (3TC) or ZDV Plus 3TC Plus Indinavir

Coverage provided by Michael Giordano, M.D.

June 30, 1998

In this study of an issue that has implications for public health and for clinical care of patients with HIV, a team from UNC examined the effect of antiviral therapy on HIV in blood and in semen, and discussed whether transmission of resistant virus could occur even when a patient is using effective anti-HIV medications.

The study enrolled 15 men with CD4 cell counts below 200, at least 6 months of ZDV (AZT) use, and no prior indinavir or 3TC use, and randomized then to a double-blinded regimen of either AZT/3TC/placebo or AZT/3TC/indinavir. Ten were randomized to the three drug arm and 5 to the two drug arm. Both arms had similar baseline semen and blood HIV levels, around 3.5 logs and 4.8 logs respectively. Semen plasma HIV levels could be measured down to the 1000 copies/mL level, while blood plasma was measured to the 400 copies/mL level.

After 24 weeks of treatment, semen HIV levels were below detection in 90% of the men in the triple combination arm, and in 80% of the two-drug arm, while blood HIV levels were undetectable in 80% and 60% respectively.

The researchers concluded that while effective antiretroviral therapy can reduce the levels of HIV in semen, the chance for HIV transmission still exists, given the lack of uniform response to therapy and the limits of sensitivity of the semen HIV viral load test. Additionally, since semen can be found when a patient is on antiviral treatment, the chance for transmission of resistant HIV also exists. This study provides further evidence that transmission prevention efforts are doubly important in the age of HAART.




This article was provided by TheBodyPRO.com. Copyright Body Health Resources Corporation. All rights reserved.

You can find this article online by typing the following address into your Web browser:
http://www.thebody.com/content/art14667.html

Please Note: Knowledge about HIV changes rapidly. Note the date of this article's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this article.

General Disclaimer: The Body is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your healthcare provider.