Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: Expert Opinions on HIV Cure Research
  
  • Email Email
  • Glossary Glossary
The Body Covers: The 12th International AIDS Conference
Poster Session 22339: A Comparison Between Seminal Plasma RNA and Blood Plasma RNA in HIV+ Men Who Receive Either Zidovudine (ZDV) Plus Lamuvidine (3TC) or ZDV Plus 3TC Plus Indinavir

June 30, 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

In this study of an issue that has implications for public health and for clinical care of patients with HIV, a team from UNC examined the effect of antiviral therapy on HIV in blood and in semen, and discussed whether transmission of resistant virus could occur even when a patient is using effective anti-HIV medications.

The study enrolled 15 men with CD4 cell counts below 200, at least 6 months of ZDV (AZT) use, and no prior indinavir or 3TC use, and randomized then to a double-blinded regimen of either AZT/3TC/placebo or AZT/3TC/indinavir. Ten were randomized to the three drug arm and 5 to the two drug arm. Both arms had similar baseline semen and blood HIV levels, around 3.5 logs and 4.8 logs respectively. Semen plasma HIV levels could be measured down to the 1000 copies/mL level, while blood plasma was measured to the 400 copies/mL level.

After 24 weeks of treatment, semen HIV levels were below detection in 90% of the men in the triple combination arm, and in 80% of the two-drug arm, while blood HIV levels were undetectable in 80% and 60% respectively.

The researchers concluded that while effective antiretroviral therapy can reduce the levels of HIV in semen, the chance for HIV transmission still exists, given the lack of uniform response to therapy and the limits of sensitivity of the semen HIV viral load test. Additionally, since semen can be found when a patient is on antiviral treatment, the chance for transmission of resistant HIV also exists. This study provides further evidence that transmission prevention efforts are doubly important in the age of HAART.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Reference

Abstract: A Comparison Between Seminal Plasma RNA and Blood Plasma RNA in HIV+ Men Who Receive Either Zidovudine (ZDV) Plus Lamuvidine (3TC) or ZDV Plus 3TC Plus Indinavir
Authored by: Luigi Troiani

See Also
More Research on HIV Prevention



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement